Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Claudia Christian: Advocate for the Sinclair Method
Bruce Rose Published on: 23/09/2025
Claudia Christian, best known for her acting roles in Babylon 5 and 9‑1‑1, is also the founder and CEO of the C Three Foundation. She is a passionate proponent of The Sinclair Method as a science-based medication-assisted approach to alcohol use disorder
The Sinclair Method (TSM)
Does The Sinclair Method Work? A Closer Look Compared to Abstinence-Based Recovery
Published on: 25/03/2025
The Sinclair Method is a form of medication-assisted treatment that uses opioid-blocking medication—typically naltrexone or nalmefene—to retrain the brain’s response to alcohol. The method is based on a process called pharmacological extinction, which reduces the reward associated with alcohol over time.
The Sinclair Method (TSM)
